Commentary: Torpor: The Rise and Fall of 3-Monoiodothyronamine from Brain to Gut—From Gut to Brain?

摘要

In this issue of Frontiers in Endocrinolgy, Glossman and Lutz present an interesting review of the pharmacological effects of 3-iodothyronamine (T1AM) reported in literature questioning the relevance of T1AM hibernating activity. For the first time, pharmacological effects of the amine are discussed in the context of its pharmacodynamic and pharmacokinetic properties. The authors’ analysis reveals discrepancies and possible misinterpretation of results which might have led to an overestimation of T1AM pharmacological profile.