Rapid Eye Movement Sleep Deprivation Produces Long-Term Detrimental Effects in Spatial Memory and Modifies the Cellular Composition of the Subgranular Zone

摘要

FIGURE 1. Experimental design. Mice were exposed to REM sleep deprivation for 72-h. Twenty-one days later, we evaluated spatial memory (Barnes maze). Cellular analysis was done at different time points to assess: proliferation, differentiation and maturation of SGZ neural progenitors, as well as apoptosis (TUNEL) and expression levels of IGF-1R.