Adipocytokines, Neuropeptide Y and Insulin Resistance in Overweight Women with Gynoid and Android Type of Adipose Tissue Distribution

摘要

The AIM of the study was to compare the levels of certain adipose tissue hormones inwomen with the two main morphological types of obesity - android and gynoid obesity.MATERIALS AND METHODS: The study included 2 groups of age- and weight-matched womenwith android (n = 32) and gynoid (n = 27) type of obesity, and a group of age-matchedhealthy women (n = 24) with normal weight and body constitution. Leptin, resistin, tumournecrosis factor α (TNFα), neuropeptide Y (NPY), glucose and insulin were measured.HOMA index was calculated.RESULTS: Leptin levels in the women with gynoid obesity did not differ significantly fromthose in the controls and the women with android obesity. The controls had significantlylower leptin levels compared with the android obesity women. NPY was significantly higherin the control women compared to the women with android obesity and did not differ significantly between the two groups of obese women. TNFα levels in all groups were verysimilar. Resistin did not show significant differences between all groups but tended to havethe lowest levels in the controls. In the women with android obesity, insulin was significantlyhigher than that in the women with gynoid obesity and the controls. Insulin resistancewas found in the women with android obesity only. Basal insulin and HOMA index in thewomen with gynoid obesity did not differ significantly from the values in the control group.CONCLUSION: The results from this study contribute to understanding the association ofadipose tissue hormones and insulin resistance in obesity. When adipose tissue is predominantlydistributed in the abdominal area at similar amount and percentage of body fats,leptin production is higher and insulin resistance develops. In the gynoid type of adiposetissue predisposition, overt insulin resistance is not found, leptin levels does not differ significantly from those in the control group.