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Mitochondrial replacement therapy and parenthood

机译:线粒体替代治疗和生育

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The year 2015 has been a decisive year for the future of mitochondrial replacement therapy (MRT) – at least in the Western world. Currently, the UK and the US governments are undergoing a process of ethical and scientific evaluation of the technique to decide whether to allow its implementation or not. MRT requires the fusion of the DNA of three parents (although of a minimal percentage in the case of one of the two female genitors) into an embryo – and this creates a number of worries as to what this scientific innovation will lead to. These worries might be well placed and worthy of consideration, but not on the grounds presented by some opponents. In this paper, we will analyse a recent European Union (EU) petition that urged the UK government (but which could be applied to the US government as well) to refrain from legalising MRT, stressing that other techniques, such as preimplantation genetic diagnosis (PGD), already have a more direct eugenic potential than MRT. Although the UK Parliament recently voted in favour of MRT, an analysis of the EU petition can nonetheless still contribute to understanding some of the key aspects of the debate. Our conclusion is that what seems to be really at stake, instead, is whether or not we are willing to reconceptualise our notion of parenthood as something not necessarily binominal and genetically related.
机译:至少在西方世界,2015年对于线粒体替代疗法(MRT)的未来而言是决定性的一年。当前,英国和美国政府正在对该技术进行道德和科学评估,以决定是否允许其实施。 MRT要求将三个亲本的DNA融合在一起(尽管对于两个女性生殖器中的一个而言只有很小的百分比)融合到胚胎中,这使人们对这种科学创新将导致的后果产生了许多担忧。这些担忧可能会妥善解决,值得考虑,但并非以某些反对者提出的理由为依据。在本文中,我们将分析欧盟最近的一份请愿书,该请愿书敦促英国政府(但也可能适用于美国政府)不要使MRT合法化,并强调其他技术,例如植入前基因诊断( PGD​​)已经比MRT具有更直接的优生潜力。尽管英国议会最近投票赞成捷运,但对欧盟请愿书的分析仍然可以帮助理解辩论的一些关键方面。我们的结论是,似乎真正处于危险之中的是我们是否愿意将我们的父母观念重新概念化为不一定与二项式和遗传相关的东西。

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