An alternate synthesis of levetiracetam

Ravikumar Mylavarapu; Ramasamy Vijaya Anand; Golla China Mala Kondaiah; Lekkala Amarnath Reddy; Gade Srinivas Reddy; Arnab Roy; Apurba Bhattacharya; Kagga Mukkanti; Rakeshwar Bandichhor

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An alternate synthesis of levetiracetam

机译：左乙拉西坦的替代合成

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Development of a new strategy for the synthesis of levetiracetam 1 is described. This strategy involves solvent-free condensation, metal-catalyzed oxidation, and amidation. Solvent-free condensation and metal-catalyzed oxidation make this synthesis a more eco-friendly alternative for the synthesis of levetiracetam.

机译：描述了合成左乙拉西坦1的新策略的发展。该策略涉及无溶剂缩合，金属催化的氧化和酰胺化。无溶剂缩合和金属催化氧化使该合成成为左乙拉西坦合成的更环保替代品。

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《Green Chemistry Letters and Reviews 》 |2010年第3期| 共6页
作者
Ravikumar Mylavarapu; Ramasamy Vijaya Anand; Golla China Mala Kondaiah; Lekkala Amarnath Reddy; Gade Srinivas Reddy; Arnab Roy; Apurba Bhattacharya; Kagga Mukkanti; Rakeshwar Bandichhor;
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中图分类化学 ;
关键词
solvent-free condensationmetal-catalyzed oxidationamidationlevetiracetam;

机译：无溶剂缩合金属催化氧化酰胺化左乙拉西坦;

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1. An alternate synthesis of levetiracetam [J] . Ravikumar Mylavarapu, Ramasamy Vijaya Anand, Golla China Mala Kondaiah, Green Chemistry Letters and Reviews . 2010 ,第1a4期

机译：左乙拉西坦的替代合成
2. An alternate synthesis of levetiracetam [J] . Ravikumar Mylavarapua Ramasamy Vijaya Ananda Golla China Mala Kondaiaha Lekkala Amarnath Reddya Gade Srinivas Reddya Arnab Roya Apurba Bhattacharyaa Kagga Mukkantib Rakeshwar Bandichhora* Green Chemistry Letters and Reviews . 2010 ,第3期

机译：左乙拉西坦的替代合成
3. Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats. [J] . van Vliet EA, Edelbroek PM, Gorter JA Epilepsia: Journal of the International League against Epilepsy . 2010 ,第3期

机译：通过交替治疗左乙拉西坦和丙戊酸盐可改善癫痫大鼠的癫痫发作控制。
4. Successful Control of Seizure Activity with Levetiracetam in an African Grey Parrot (Psittacus erithacus) After Eight Years of Inadequate Control [C] . Annual Conference and Expo of the Association of Avian Veterinarians . 2017

机译：在八年的控制不足之下，在非洲灰鹦鹉（Psittacus Irithacus）中的Levetiracetam对癫痫发作活动的成功控制
5. I. TOTAL SYNTHESIS OF DL-CARNOSIC ACID DIMETHYL ETHER. II. ALTERNATE APPROACHES TO THE INTRODUCTION OF II-OXYGEN SUBSTITUENTS: TOTAL SYNTHESISOF DL-CARNOSOL DIMETHYL ETHER. [D] . SHEW, DELBERT CRAIG. 1969

机译：I.总的DL-己二酸二甲醚的合成。二。引入II-氧取代基的替代方法：完全合成DL-香辛醇二甲醚。
6. Radiosynthesis of 11C-Levetiracetam:A Potential Marker for PET Imaging of SV2A Expression [O] . Hancheng Cai, *, Thomas J. Mangner, 2014

机译：11C-左乙拉西坦的放射合成：用于SV2A表达的PET成像的潜在标记
7. Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats [O] . van Vliet, E.A., Edelbroek, P.M., Gorter, J.A. 2010

机译：左乙拉西坦和丙戊酸盐交替治疗改善癫痫发作的控制

An alternate synthesis of levetiracetam

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