An efficient and practical synthesis of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazole using silica-supported sodium hydrogen sulfate as a heterogeneous catalyst

摘要

Silica-supported sodium hydrogen sulfate (NaHSO4·SiO2) efficiently catalyzed the three-component reactions of o-phenylenediamine, 2-mercaptoacetic acid, and aromatic aldehydes, and it formed the corresponding 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazole. The catalyst is inexpensive and eco-friendly and works under heterogeneous conditions.