Evaluation of the Efficacy of Simultaneous Vaccination of Cattle Against Rabies and Foot and Mouth Disease Viruses

摘要

Rabies and foot and mouth disease (FMD) are viral diseases affecting cattle in dramatic formsleading to great economic losses. To evaluate the serological response of cattle to the locally produced trivalentFMD and rabies virus vaccines when administrated separately or simultaneously, 30 native breed calves weredivided into 6 groups where the 1st group was vaccinated S/C with the trivalent oil FMD vaccine by a dose of2ml/animal. The 2nd group was vaccinated S/C with rabies vaccine by a dose of 4ml/animal. While the 3rd and4th groups were vaccinated with the trivalent oil FMD vaccine one week before and after vaccination with therabies vaccine respectively. Group-5 was simultaneously vaccinated with both trivalent oil FMD vaccine andrabies vaccine. While 6th group was kept unvaccinated as a control. The immune response of calves for bothvaccines was monitored by serum neutralization test and ELISA. The results revealed that both inactivatedrabies and trivalent FMD vaccines were safe without local or systemic post vaccinal reactions in vaccinatedcalves. It was observed that both vaccines were immunogenic leading protective levels of specific rabies andFMD (type O, A and SAT-2).