Translesion DNA Synthesis and Hsp90

摘要

References(55) Translesion DNA synthesis (TLS) is an essential mechanism for DNA damage tolerance during genome duplication by bypassing DNA lesions with use of specialized low-fidelity polymerases. Thus, TLS is inherently mutagenic, which is presumed to be involved in cancer initiation and progression. Increasing attention has focused on post-translational regulatory mechanisms of TLS polymerases, including covalent modification (e.g., phosphorylation) and proteasomal degradation. In this review article, we focus on our findings on Hsp90-mediated regulation of TLS polymerases and discuss potential pharmacological effects of Hsp90 inhibitors in cancer therapy.