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MODA: An efficient algorithm for network motif discovery in biological networks

机译:MODA:在生物网络中发现网络主题的有效算法

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References(38) Cited-By(17) In recent years, interest has been growing in the study of complex networks. Since Erdös and Rényi (1960) proposed their random graph model about 50 years ago, many researchers have investigated and shaped this field. Many indicators have been proposed to assess the global features of networks. Recently, an active research area has developed in studying local features named motifs as the building blocks of networks. Unfortunately, network motif discovery is a computationally hard problem and finding rather large motifs (larger than 8 nodes) by means of current algorithms is impractical as it demands too much computational effort. In this paper, we present a new algorithm (MODA) that incorporates techniques such as a pattern growth approach for extracting larger motifs efficiently. We have tested our algorithm and found it able to identify larger motifs with more than 8 nodes more efficiently than most of the current state-of-the-art motif discovery algorithms. While most of the algorithms rely on induced subgraphs as motifs of the networks, MODA is able to extract both induced and non-induced subgraphs simultaneously. The MODA source code is freely available at: http://LBB.ut.ac.ir/Download/LBBsoft/MODA/
机译:参考文献(38)被引用者(17)近年来,对复杂网络的研究越来越引起人们的兴趣。自从Erdös和Rényi(1960)在大约50年前提出他们的随机图模型以来,许多研究人员已经对该领域进行了研究和塑造。已经提出了许多指标来评估网络的全球特征。最近,一个活跃的研究领域已经发展成为研究以主题为主题的局部特征(作为网络的基础)。不幸的是,网络主题发现是一个计算难题,而通过当前算法来找到相当大的主题(大于8个节点)是不切实际的,因为它需要太多的计算工作。在本文中,我们提出了一种新算法(MODA),该算法结合了诸如模式增长方法之类的技术,可以有效地提取较大的图案。我们已经测试了我们的算法,发现它比大多数当前最先进的主题发现算法能够更有效地识别8个以上节点的更大主题。尽管大多数算法都将诱导子图作为网络的主题,但MODA能够同时提取诱导子图和非诱导子图。可在以下位置免费获得MODA源代码:http://LBB.ut.ac.ir/Download/LBBsoft/MODA/

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