Augmentative effect of prostaglandin E1 on pentobarbital hypnosis mediated by 5-HT in chicks

摘要

Prostaglandins (PG) are present in different tissues specially in brain tissues endowed with differentcentral nervous system activities. Similarly, 5-hydroxytryptamine (5-HT) a biogenic amine with its presencein different central and peripheral tissues as neurotransmitter plays an important role in the regulation of physiologicalfunctions specially hypnosis, convulsions, analgesia in rats, mice, cats and chicks etc. Pentobarbitone(PB) induced sleep appear to be a serotonergic modulator activity in different animals. PGE1 potentiates thepentobarbitone hypnosis also mediated through serotonin. In the present study, PGE1 induced sleeping time inchicks was evaluated. Drugs affecting 5-HT synthesis, metabolism and receptor activity modulate the potentiatingresponse, while adrenergic receptor antagonists did not showed any response. This study suggest that PGE1potentiate PB induced sleep through serotonergic signaling pathway as PGE1 increased 5-HT synthesis rate inchick brain.