Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1

摘要

Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in China, but the underlying molecular mechanism of {ESCC} is still unclear. Involvement of microRNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in {ESCC} remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in {ESCC} tissue relative to adjacent normal tissues. Further investigation in the effect of miR-503 on {ESCC} cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited {ESCC} aggressive phenotype and overexpression of {CCND1} reversed the effect of miR-503-mediated {ESCC} cell aggressive phenotype. Our study further identified {CCND1} as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in {ESCC} by targeting CCND1.