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Transcriptional profiling of differentially expressed long non-coding RNAs in breast cancer

机译:乳腺癌中差异表达的长非编码RNA的转录谱分析

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Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that have been recently shown to play critical roles in cancer biology. However, little is known about their mechanistic role in breast cancer pathogenesis, especially in triple-negative breast carcinomas (TNBC) that have particular poor outcomes.This study was specifically designed to identify the signatures relevant lncRNAs in breast cancer and characterize lncRNAs that modulate the phenotype. Here we provide detailed methods and analysis of microarray data, which is deposited in the Gene Expression Omnibus (GEO) with the accession number GSE64790 . The basic analysis as contained in the manuscript published in Oncotarget with the PMID 26078338. These data can be used to further elucidate the mechanisms of breast cancer. 1 These authors contributed equally to this work. Copyright ? 2015 Elsevier Inc. No articles found. Citing articles View article metrics Elsevier About ScienceDirect Remote access Shopping cart Contact and support Terms and conditions Privacy policy We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies .Copyright ? 2018 Elsevier B.V. or its licensors or contributors. ScienceDirect ? is a registered trademark of Elsevier B.V. RELX Group.
机译:长非编码RNA(lncRNA)是非编码RNA的子类,最近已显示在癌症生物学中起关键作用。然而,关于它们在乳腺癌发病机制中的作用机制的了解甚少,尤其是在三阴性乳腺癌(TNBC)中,其结果特别差。这项研究是专门设计用于鉴定乳腺癌中相关lncRNA的特征并鉴定可调控乳腺癌基因的lncRNA。表型。在这里,我们提供了微阵列数据的详细方法和分析,该数据以登录号GSE64790存放在Gene Expression Omnibus(GEO)中。基本分析包含在Oncotarget中以PMID 26078338发表的手稿中。这些数据可用于进一步阐明乳腺癌的机制。 1 这些作者同样为这项工作做出了贡献。版权? 2015 Elsevier Inc.找不到文章。引用文章查看文章度量标准Elsevier关于ScienceDirect远程访问购物车联系和支持条款和条件隐私权政策我们使用cookie来帮助提供和增强我们的服务,并定制内容和广告。如果继续,您同意使用Cookies。版权所有? 2018 Elsevier B.V.或其许可人或贡献者。 ScienceDirect?是Elsevier B.V. RELX Group的注册商标。

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