Complete Genome Sequence of the Novel Temperate Clostridium difficile Phage phiCDIF1296T

Johannes Wittmann; Thomas Riedel; Boyke Bunk; Cathrin Spr?er; Sabine Gronow; J?rg Overmann

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Complete Genome Sequence of the Novel Temperate Clostridium difficile Phage phiCDIF1296T

机译：新型温带艰难梭菌噬菌体phiCDIF1296T的完整基因组序列

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Clostridium difficile contains many integrated and extrachromosomal genetic elements. In this study, we determined, annotated, and analyzed the complete genome of the C.?difficile bacteriophage phiCDIF1296T using single-molecule real-time sequencing technology. To our knowledge, this represents the largest genome (131?kb) of a temperate C.?difficile phage recognized so far.

机译：艰难梭菌包含许多整合的染色体外遗传元件。在这项研究中，我们使用单分子实时测序技术确定，注释和分析了艰难梭菌噬菌体phiCDIF1296T的完整基因组。据我们所知，这代表了迄今为止公认的温带艰难梭菌噬菌体的最大基因组（131kb）。 展开▼

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《Genome Announcements》 |2015年第4期|共2页

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Johannes Wittmann; Thomas Riedel; Boyke Bunk; Cathrin Spr?er; Sabine Gronow; J?rg Overmann;
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中图分类基因工程（遗传工程）;

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专利

1. The complete genome sequence of Clostridium difficile phage ?C2 and comparisons to ?CD119 and inducible prophages of CD630 [J] . Shan Goh, Peh Fern Ong, Keang Peng Song, Microbiology . 2007,第3期

机译：Clostridium艰难梭菌噬菌体的完整基因组序列和ΔCD119和CD630的诱导型概括

2. Genome analysis of the Clostridium difficile phage PhiCD6356, a temperate phage of the Siphoviridae family. [J] . Horgan M, OSullivan O, Coffey A, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2010,第1a2期

机译：艰难梭菌噬菌体PhiCD6356（Siphoviridae家族的温带噬菌体）的基因组分析。

3. The Complete Amino Acid Sequence of the Clostridium botulinum Type D Neurotoxin, Deduced by Nucleotide Sequence Analysis of the Encoding Phage d-16φ Genome [J] . Hiroyuki SUNAGAWA, Katsuhiro INOUE, Tohru OHYAMA, The Journal of Veterinary Medical Science . 1992,第5期

机译：通过编码噬菌体d-16φ基因组的核苷酸序列分析推导出D型肉毒梭菌神经毒素的完整氨基酸序列。

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机译：评价Di-Tri-octaheDral蒙脱石粘附到梭菌腹菌毒素和梭菌梭菌中的能力

5. Finding a novel way for fast sequence alignment and exploiting information theory in bacterial genomes and complete phages. [D] . Akhter, Sajia. 2013

机译：寻找一种快速的序列比对的新方法，并利用细菌基因组和完整噬菌体中的信息论。

6. Complete Genome Sequence of the Novel Temperate Clostridium difficile Phage phiCDIF1296T [O] . Johannes Wittmann, Thomas Riedel, Boyke Bunk, 2015

机译：新型温带艰难梭菌噬菌体phiCDIF1296T的完整基因组序列

7. Complete genome sequence of the newly discovered temperate Clostridioides difficile bacteriophage phiCDKH01 of the family Siphoviridae [O] . Krzysztof Hinc, Monika Kabała, Adam Iwanicki, 2021

机译：新发现的温带梭氧化钛酸纤维素梭菌性梭菌性梭菌的完整基因组序列胞嘧啶的家庭

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2. 艰难梭菌谷氨酸脱氢酶抗原及毒素检测试剂盒对艰难梭菌感染诊断价值的Meta分析 [J] . 祁琪 ,茅一萍 ,李阳 . 中国感染控制杂志 . 2019,第006期

3. 艰难梭菌核酸检测试剂盒诊断艰难梭菌感染的多中心研究 [J] . 吴湜 ,周芬芬 ,倪语星 . 中华检验医学杂志 . 2019,第008期

4. 艰难梭菌毒素A/B、BD-PCR毒素基因及GDH检测对艰难梭菌相关性腹泻的诊断价值 [J] . 邵婧 ,丁宸 ,徐萍萍 . 标记免疫分析与临床 . 2016,第009期

5. 非产毒艰难梭菌对艰难梭菌感染BALB/c小鼠的防治作用 [J] . 王祥 ,傅思武 . 兰州大学学报（医学版） . 2009,第003期

6. 浅谈艰难梭菌感染——疾病机理、临床症状、诊断、治疗、预防与控制 [C] . 孔懿 . 江苏省医院协会医院感染管理专业委员会2018年学术年会 . 2018

7. 血液病患者产毒艰难梭菌定植和感染危险因素的前瞻性研究及临床分离艰难梭菌的耐药性分析 [A] . 王洁 . 2014

1. 一种抑制艰难梭菌菌体和/或抑制艰难梭菌芽孢萌发的药物 [P] . 中国专利： CN110478335A . 2019-11-22

2. 检测和分析艰难梭菌菌株的组合物和试剂盒及用该组合物和试剂盒检测艰难梭菌菌株的方法 [P] . 中国专利： CN103484532A . 2014-01-01

3. Fusion protein Fusion protein The soluble composition of the host cell material Process to generate a neutralizing anti-toxin directed against Clostridium botulinum toxin type A antibody to purify a recombinant fusion protein derived from a Clostridium botulinum toxin type A process to generate an antitoxin neutralizing directed against clostridium difficile toxin type b antibody treatment process process to generate a neutralizing antitoxin directed against clostridium difficile type a toxin composition process to vaccinate an individual to produce neutralizing antitoxin directed against clostridium difficile toxin processing the detection of clostridium antigens difficile in an ample process of purification of toxins from clostridium difficile from a culture and process of generation of a solid dosage form of a bird antitoxin directed against a protein of clostridial toxin [P] . 外国专利： BR9509903A . 1997-11-25

机译：融合蛋白融合蛋白宿主细胞材料的可溶性组成物产生针对A型肉毒梭菌毒素的中和抗毒素的过程纯化源自A型肉毒杆菌毒素的重组融合蛋白的抗体产生针对人肉毒杆菌的抗毒素的过程B型艰难梭菌毒素抗体处理工艺过程，产生针对A艰难梭菌毒素的中和抗毒素组合物，对个体进行疫苗接种，以生产针对艰难梭菌毒素的中和抗毒素，在充足的纯化纯化过程中检测艰难梭菌抗原来源于梭状芽胞杆菌毒素蛋白的鸟抗毒素固体剂型的培养物和固体剂型产生过程中的艰难梭菌毒素

4. Use in the manufacture of a medicament of an antibody having specific activity against Clostridium difficile, and pharmaceutical compositions comprising Anti-Clostridium difficile bovine immunoglobulin concentrate; for treating diseases associated with Clostridium difficile [P] . 外国专利： NZ291659A . 2001-04-27

机译：用于制造对艰难梭菌具有特定活性的抗体的药物，以及包含抗艰难梭菌牛免疫球蛋白浓缩物的药物组合物;用于治疗艰难梭菌相关疾病

5. Clostridium difficile Clostridium scindens having inhibitory effect against Clostridium difficile [P] . 外国专利： KR102323783B1 . 2021-11-09

机译：Clostridium艰难梭菌芯片芯片对梭菌性艰难梭菌具有抑制作用

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Complete Genome Sequence of the Novel Temperate Clostridium difficile Phage phiCDIF1296T

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