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Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males

机译:载脂蛋白L1基因多态性及其对中年男性血脂和血糖水平的影响

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Apolipoprotein L1 in plasma is associated with high-density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lysl66Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males.
机译:血浆中的载脂蛋白L1与高密度脂蛋白有关。研究了新型APOL1多态性,以及两种常见单倍型(Lysl66Glu,Ile244Met,Lys271Arg)与循环脂质和葡萄糖水平的关联。尽管氨基酸取代发生在参与脂质结合的两亲性α螺旋区域中,但发现这些取代并不能独立说明149名中年男性循环脂质和葡萄糖水平的变异性。

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