MicroRNAs in endometrial cancer: recent advances and potential clinical applications

摘要

Endometrial cancer is a common malignant gynecological tumor, but there are few biomarkers that are useful forearly and accurate diagnosis and few treatments other than surgery. However, use of microRNAs (miRNAs) thatinduces gene downregulation in cells may permit effective and minimally invasive diagnosis and treatment. Inendometrial cancer cells, expression levels of miRNAs including miR-185, miR-210 and miR-423 are upregulatedand those of miR-let7e, miR-30c and miR-221 are downregulated compared to normal tissues, and thesemiRNAs are involved in carcinogenesis, invasion and metastasis. miRNAs with expression changes such asmiR-181b, miR-324-3p and miR-518b may be used as prognostic biomarkers and transfection of miR-152 mayinhibit cancer growth. However, most current studies of miRNAs are at a basic level and further work is neededto establish clinical applications targeting miRNAs.