The study of the relationship between aberrant expression of hot shock protein 70 (HSP70) and spontaneous abortion

摘要

OBJECTIVE: The present study is aimed to explore the relationship between aberrant expression of heat shock protein 70 (HSP) and spontaneous abortion. PATIENTS AND METHODS: 50 patients with spontaneous abortion and 50 patients with induced abortion were continuously selected based on the nearest matching principle, and the proportion of age and gestational age was 1:1. The decidual tissues were obtained, and the cell apoptosis was determined by TUNEL assay. Further, the expression of HSP70 was assayed by immune-histochemical staining, and the expression of HSP70 mRNA was detected by the RT-PCR approach. RESULTS: Apoptosis rate, HSP70 expression and HSP70 mRNA expression in the observation group were significantly higher than the control group. CONCLUSIONS: HSP70 might induce apoptosis so as to cause spontaneous abortion.