Effection of myocardial cell/collagen compound on ventricular electrophysiology in rats with myocardial infarction

摘要

OBJECTIVE: Microelectrode array (MEA) technique could synchronous record of electrical activity for many cardiac cells to detect the interval difference between excitation produced by the same pacemaker cell or different pacemaker cell to different electrodes. In this experiment study, the MEA technique was applied to study cardiac cells/collagen complex affected the electrophysiological properties in rat ventricular muscle and expound the discovery that cardiac cells/collagen complex can repair rat heart functions. MATERIALS AND METHODS: Thirty SD rats were evenly divided into three groups: control group, myocardial infarction group and transplantation group. The control group underwent thoracotomy without coronary artery ligation. The transplantation group was transplanted with tissues compounded with myocardial cells and collagen materials after the model was established. The amplitude and the activation-recovery interval of myocardium were recorded. RESULTS: The field amplitude of the ventricular myocardium in the infarction zone, opposite zone and border zone in the transplantation group increased compared with the MI group. The activation-recovery interval in the MI group, as well as the infarction zone and infarcted border zone in the transplantation group, was variously prolonged (p < 0.05). CONCLUSIONS: Myocardial cell/collagen compound could replace infarction tissues and improve electrophysiological characteristics in myocardial infarction rat, partly repair function of the heart.