The Local Blood Flow Changes in the Cerebral Cortex with Ischemic Pretreatment under Inhibitors Use

摘要

The aim of this study was examination of the Nitric Oxide role in realization of ischemic preconditioning phenomenon. Experiments were carried out in white rats. Ischemic preconditioning was accomplished by occlusion of the common carodit artery. Cerebrocortical blood flow was measured by Hydrogen clearance technique. Intraperitoneal injection of Nitro-L-arginine-metil ester (L-NAME) resulted in complete suppression of preconditioning, while selective inhibitor of inducible NOS – aminoguanidinsuppessed it just partially.