Hepatoprotective Activity of Rubia tinctorum’s Extract against CCl4 Induced Hepatic Injury in Rats

摘要

This study investigated the hepatoprotective activity of Rubia tinctorum’s extract against CCl₄ induced liver damage in rats. Twenty four rats were divided into four groups. Group I received normal saline (10 ml/kg) and group II (normal control) was treated with vehicle (olive oil 1 ml/kg), Group III (CCl₄ control) received 1 ml/kg CCl₄ mixed with equal volume of olive oil and Group IV (test group) received simultaneously the extract (1 g/kg) + CCl₄ for 15 days. At the end of the experiment (2 weeks), blood and liver samples were collected for biochemical and histopathological analysis. The present study revealed that CCl₄ significantly increased ( P Rubia tinctorum’s extract. Histopathologically, the potential hepatoprotective (the hepatoprotective potential of the plant) activity of the plant was also revealed by its regenerative action on CCl₄ induced liver tissues injury. This finding indicates that Rubia tinctorum L has a potent hepatoprotective effect against CCl₄-induced liver damage and improved the biochemical and histopathological results.