Efficacy of losartan and combination of losartan plus hydrochlorothiazide for high blood pressure treatment

摘要

Hypertension?is?one?of?the?most?common?cardiovascular?risk?factors?in?adult?population.?Evenvalues?of?high?normal?blood?pressure?are?linked?to?increased?risk?of?major?cardiovascularevents?and?only?minority?of?patients?reach?the?target?values?with?antihypertensive medications prescribed.?We wanted to??demonstrate?the?efficacy?and?safety?of?treatment?with?losartanand/or?combination?of?losartan?plus?hydrochlorothiazide?in?middle?aged?population?with?mostfrequent?cardiovascular?risk?factors. We conducted a multicenter,?prospective,?observational, non-randomized?study?over?10?weeks?in?patients?with?essential?hypertension?whose?bloodpressure?was?not?adequately?controlled?despite?previously prescribed antihypertensive therapy.?Main?outcome?parameters?were?systolic?and?diastolic?blood?pressure?reduction andthe?rate?of?normalization of blood pressure?at?study?end,?comparing?to?baseline.?595?patients were included in the study,?313?men?and?281?women?(1?of?the?participant’s?sex?was?notdetermined),?with?mean?age?of?63.1 ± 10.0?years.?Patients?received?losartan?and/or?losartanplus?hydrochlorothiazide?instead?or?on?top?of?their?previous?antihypertensive?medications.Average?blood?pressure?was?lowered?from?(158?±?13)/(95?±?9) mmHg to (137?±?10)/(84?±?8) mmHg and (157?±?15)/(92?±?9) mmHg to (136?±?12)/(82?±?8) mmHg in non-diabetic and diabetic patients?respectively?(P<0.05).?Average blood pressure reduction was 21/11 mmHg for non-diabetic patients while reduction of blood pressure for diabetic patients was 20/11 mmHg.?Target?blood?pressure?attainment?rates?were?higher?in?non-diabetic patients.?From our results we?may?conclude?that losartan and/or?combination?of losartan plus hydrochlorothiazideare effective and potent antihypertensive agents and could be used in high risk?non-diabeticand?diabetic?patient?due?to?its?neutral and some beneficial metabolic effects.