Analgesic and anti-inflammatory effect of whole Ageratum conyzoides and Emilia sonchifolia alcoholic extracts in animal models

摘要

This study was designed to investigate the analgesic and anti-inflammatory effects ofAgeratum conyzoides?and?Emilia sonchifolia?alcoholic extracts in animal models.?Analgesic effects have been investigated in acetic acid induced writhing model and formalin induced licking model of Swiss albino mice. Anti-inflammatory effect was investigated in carrageenan induced anti-inflammatory paw edema model of Wistar albino rat. Data were analyzed by one-way analysis of variance (ANOVA), followed by Tukey's post hoc test for multiple comparisons. In a dose-dependent response,?A. conyzoides?and?E. sonchifolia?extracts inhibited 49.85 and 39.47% of acetic acid induced pain at the highest dose 2.0 g/kg body weight (BW). These effects were statistically significant (P < 0.05) as compared to the reference drug, diclofenac sodium (40 mg/kg).?A. conyzoides?reduced 35.48% and?E. sonchifolia?reduced 38.70% of formalin induced pain by 2.0 g/kg which were also statistically significant (P < 0.05) as compared to morphine (0.5 mg/kg). In a time-dependent inhibition of carrageenan induced paw edema model, the extracts of?A. conyzoides?and?E. sonchifoliapromoted 50.23 and 48.11% inhibition of paw edema at the 4th hour of administration, respectively and the effects were statistically significant (P < 0.05). No mortality was observed in acute toxicity test. Observed results demonstrate an effective analgesic and anti-inflammatory potentials of the extracts to be used as complementary and alternative therapy.