Effect of Salvia miltiorrhiza extract on blood lipid, hydroxyproline levels, skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats

摘要

The purpose of the present study was to examine the effects of aqueous extract of?Salvia miltiorrhiza?on plasma lipid and hydroxyproline levels and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats. Adult Sprague-Dawley male rats, 3 months of age, were assigned randomly to a sedentary control (n = 10) or exercise (n = 10) group or SME-treatent groups (exercise + SME) (n = 10 in each group). Ten animals in sedentary control group did not receive any exercise. Animals in exercise group received exercise. Animals in SME-treatent groups (exercise + SME) received exercise orally given withS. miltiorrhiza?extract (50, 100 or 150 mg/kg body weight), respectively. Result showed that aqueous extract of?S. miltiorrhiza?can decrease blood total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c) and increase high-density lipoprotein cholesterol (HDL-c) levels, enhance hydroxyproline levels in bone, skeletal muscle, heart and lung, and skeletal muscle Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in swimming exercise rats.