Emergence of IntI1 associated bla_VIM-2 gene cassette-mediated carbapenem resistance in opportunistic pathogen Pseudomonas stutzeri

摘要

Dear Editor, Carbapenems are considered as the last resort of antibiotic for the treatment of infection but many Gram-negative organisms have developed resistance to this antibiotic through loss or alteration of outer membrane porin protein OprD, over-expression of efflux pump, hyperproduction of an AmpC-type-β-lactamase and/or carbapenemase. 1 Carbapenemases are β-lactamases with catalytic efficiencies for carbapenem hydrolysis, including enzymes from Ambler’s classes A (extended spectrum β-lactamase), B (metallo-β-lacatamase, MBL) and D (Oxacillinases, OXA). The serine carbapenemases are derivatives of class A (e.g., IMI, KPC, GES) and class D enzymes (e.g., OXA-23, OXA-40, OXA-48) that hydrolyze carbapenems poorly but able to confer resistance.