Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated byGeotrichum candidumCCT 1205 andRhodotorula glutinisCCT 2182

摘要

Enantioselective reductions ofp-R1-C6H4C(O)CH2R2(R1= Cl, Br, CH3, OCH3, NO2and R2= Br, Cl) mediated byGeotrichum candidumCCT 1205 andRhodotorula glutinisCCT 2182 afforded the corresponding halohydrins with complementaryRandSconfigurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries.