Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response

Eva Klimc?a?kova?; Balbine Roussel; Adriana Ma?rquez-Quin?ones; Zuzana Kova?c?ova?; Michaela Kova?c?ikova?; Marion Combes; Michaela S?iklova?-Vi?tkova?; Jindra Hejnova?; Petra S?ra?mkova?; Anne Bouloumie?; Nathalie Viguerie; Vladimir S?tich; Dominique Langin

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Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response

机译：肥胖和代谢状态的恶化在人类皮下和内脏脂肪组织中产生相似的分子适应性：代谢减少和免疫反应增加

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ContextIt is not known whether biological differences reported between sc adipose tissue (SAT) and visceral adipose tissue (VAT) depots underlie the pathogenicity of visceral fat.

机译：尚不清楚sc脂肪组织（SAT）和内脏脂肪组织（VAT）储库之间报告的生物学差异是否是内脏脂肪的致病性基础。

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《Endocrine Reviews》 |2010年第6期|共1页
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Eva Klimc?a?kova?; Balbine Roussel; Adriana Ma?rquez-Quin?ones; Zuzana Kova?c?ova?; Michaela Kova?c?ikova?; Marion Combes; Michaela S?iklova?-Vi?tkova?; Jindra Hejnova?; Petra S?ra?mkova?; Anne Bouloumie?; Nathalie Viguerie; Vladimir S?tich; Dominique Langin;
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中图分类内分泌腺疾病及代谢病;
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1. Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response [J] . Eva Klimc?a?kova?, Balbine Roussel, Adriana Ma?rquez-Quin?ones, The journal of clinical endocrinology and metabolism . 2011,第1期

机译：肥胖和代谢状态的恶化在人类皮下和内脏脂肪组织中产生相似的分子适应性：代谢减少和免疫反应增加
2. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions. [J] . Julie. Lessard, André. Tchernof Clinical lipidology. . 2012,第5期

机译：脂肪形成与肥胖相关的差异已知脂肪细胞肥大和增生分别通过增加脂肪细胞的大小和数量来促进脂质在脂肪组织中的存储。脂肪形成是导致脂肪组织增生的过程。尽管已经有很多文献记载了贮库特异性差异和肥胖相关的脂肪细胞大小调节，但有关脂肪形成和脂肪组织增生的可用数据尚无定论。大多数研究支持在肥胖状态下减少脂肪形成。在大多数研究中，与来自内脏脂肪区室的脂肪细胞相比，皮下脂肪库的前脂肪细胞似乎对脂肪刺激更为敏感。许多研究支持这样的观点，即通过增生的脂肪组织扩张可以减少异位脂质过多和肥胖相关的并发症。在编码脂肪形成调节蛋白的基因中已经鉴定出几种遗传变异。尽管其中一些变异与肥胖症的表型和与肥胖有关的改变明显相关，但现有数据突出了考虑基因-基因和基因-饮食相互作用的重要性。
3. Differences in the redox status of human visceral and subcutaneous adipose tissues - Relationships to obesity and metabolic risk [J] . JankovicA., KoracA., Srdic-GalicB., Metabolism: Clinical and Experimental . 2014,第5期

机译：人体内脏和皮下脂肪组织氧化还原状态的差异-与肥胖和代谢风险的关系
4. The molecular regulation of visceral and subcutaneous adipose tissue lipolysis by AMP-activated protein kinase. [D] . Anthony, Nicole Marie. 2009

机译：AMP激活的蛋白激酶对内脏和皮下脂肪组织脂解的分子调控。
5. Characterization of visceral and subcutaneous adipose tissue transcriptome in pregnant women with and without spontaneous labor at term: Implication of alternative splicing in the metabolic adaptations of adipose tissue to parturition [O] . Shali Mazaki-Tovi, Adi L. Tarca, Edi Vaisbuch, -1

机译：足月分娩和不分娩的孕妇内脏和皮下脂肪组织转录组的特征：替代剪接对脂肪组织对分娩的代谢适应的影响
6. Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. [O] . Klimcáková, Eva, Roussel, Balbine, Kovácová, Zuzana, 2011

机译：肥胖和新陈代谢状况的恶化会在人的皮下和内脏脂肪组织中产生相似的分子适应性：新陈代谢降低和免疫反应增强。

Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response

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