Mucosal breaks show same circumferential distribution in majority of patients with recurrent reflux esophagitis

摘要

Background and study aims?Esophageal mucosal breaks in patients with reflux esophagitis (RE) have a unique circumferential distribution. However, the specific location of mucosal breaks during recurrence of RE remains unclear. We investigated the circumferential distribution of mucosal breaks in patients with recurrent RE and compared their location to that noted at the initial diagnosis. Patients and methods?We retrospectively enrolled patients with recurrent RE with Los Angeles (LA) grade A-C who were treated at our University Hospital between July 1996 and June 2014.?The circumferential distribution of esophageal mucosal breaks was evaluated at the time of the initial diagnosis and again at the time of recurrence. Information regarding clinical parameters, including proton pump inhibitor administration, presence of hiatal hernia, and mucosal atrophy, was also reviewed. Results?A total of 114 patients with recurrent RE were examined during the study period, with a mean duration to recurrence after initial diagnosis of 39.4 months. The majority (72.8?%) had the same LA grade at recurrence. In addition, recurrent mucosal breaks in 96 (84.2?%) patients were observed to have occurred in the same circumferential location as at the initial diagnosis, while those in 18 (15.8?%) were observed in a different location. When recurrent lesions had a different location, the LA grade also tended to be different (P?=?0.02). Conclusions?We found that most patients with recurrent RE developed lesions in the same circumferential location as noted for the initial lesions. Those in different locations at recurrence were associated with a change in LA grade.