Assessment of Internal Absorbed Dose in the Human Abdominal Organs from Two Renal Radiopharmaceuticals Based on Experimental Mouse Data

摘要

Background : Radiopharmaceuticals have several applications in medicine such as imaging and therapeutic processes. Radiopharmaceutical renal scintigraphy presents important functional data to assist in the diagnosis and management of patients. Methods and findings : In this research, the human effective dose from two important renal imaging agents (SUP99m/SUPTc- MAG3 and SUP131/SUPI-Hippuran) is estimated, after injection of those in animal body. Effective dose in human body is estimated using MIRD method and MCNP simulation code (with F6 and *F8 tally) for different organs. Sources with energies of 140keV (gamma) for SUP99m/SUPTc and 364 keV (gamma), 192 keV (average energy of beta) for 131I are considered. The results of SUP99m/SUPTc-MAG3 and SUP131/SUPI-Hippuran dosimetry showed that the lung and stomach (for SUP99m/SUPTc-MAG3) and stomach and lung (for SUP131/SUPI-Hippuran) had the most effective dose relative to the other organs respectively. Conclusion : There is no good agreement between mouse model and Stabin’s human model for SUP131/SUPI-Hippuran.