OXIDATIVE STRESS AND VASCULAR DAMAGE IN HYPOXIA PROCESSES. MALONDIALDEHYDE (MDA) AS BIOMARKER FOR OXIDATIVE DAMAGE.

摘要

Changes in the levels oxidative stress biomarkers are related with different diseases such as ischemia/reperfusion, cardiovascular,renal, aging, etc. One of these biomarkers is the malondialdehyde (MDA) generated as resulted of the process of lipid peroxidation.This biomarker is increased under conditions of the oxidative stress. Their levels, have been frequently used to measure plasmaoxidative damage to lipids by their atherogenic potential. Its half-life high and their reactivity allows it to act both inside and outsideof cells and interaction with proteins and DNA involve their role in different pathophysiological processes.This paper presents an analysis of the use of MDA as a biomarker of oxidative stress and its implications associated pathologies suchas cardiovascular diseases ago.