COMPARISON OF EFFICACY OF ORAL AZITHROMYCIN WITHINTRAVENOUS CEFTRIAXONE FOR THE TREATMENTOF UNCOMPLICATED ENTERIC FEVER

摘要

OBJECTIVE: To determine the efficacy of oral azithromycin and intravenous ceftriaxone for treatment of uncomplicated enteric feverand the frequency of relapse in both groups. STUDY DESIGN: A randomized controlled trial PLACE AND DURATION: Study was conducted at Pediatric Medicine Ward and Emergency Department of Sir Ganga Ram Hospital from1^stMay 2013 to 31^stOct 2013. METHODOLOGY: Using Non probability purposive sampling, 100 patients with uncomplicated enteric fever were taken who werefulfilling the inclusion criteria. Patient was randomly divided in 2 groups using random numbers, Group "A" and Group "B", with 50 patients in each group. Group A was given ceftriaxone for 7 days. Group B was given azithromycin once a day for 7 days. A culture wasrepeated at day 4 of therapy. Both groups were compared for efficacy and relapse. RESULTS: Efficacy achieved by oral azithromycin as well as intravenous ceftriaxone in treatment of uncomplicated enteric fever wasstatistically same. There were 11 patients in Ceftriaxone group (A) with relapse. There were 3 patients in Azithromycin group withrelapse. The rate of relapse was different statistically in both groups. CONCLUSION: Efficacy achieved by both the oral azithromycin and intravenous ceftriaxone in treatment of uncomplicated entericfever was satisfactory and statistically same. However, higher rate of relapse was observed in group treated by intravenous ceftriaxonecompared to oral azithromycin.