BRIEF COMMUNICATION: ASSOCIATION OF SERUM URIC ACID WITH LEVEL OF BLOOD PRESSURE IN TYPE 2 DIABETIC PATIENTS

摘要

This study was conducted to investigate the association between serum uric acid level and blood pressure in type 2 diabetes mellitus.Sixty patients with type 2 diabetes mellitus were enrolled to the study. None of the patients had a history of gout, were treated with allopurinol, or were treated with antihypertensive drugs previously. The mean duration of DM was 9.2±4.9 years. The mean serum creatinine level was 0.98±0.22 mg/dL, and the mean serum UA level was 4.4±1.2 mg/dL. The mean protein level in 24-hour urine sample was 388±22 mg/d. The mean systolic and diastolic blood pressure values were 133.0±13.0 mm Hg and 84.0±7.4 mm Hg, respectively. There was no significant difference in levels of serum uric acid, hemoglobin A1c, serum creatinine, proteinuria, or systolic and diastolic pressure between the men and the women.A significant positive correlation was seen between serum UA and systolic (r=0.312, P=.02) and diastolic blood pressure (r=0.297, P=.03). Results of this study suggest that serum uric acid had a strong association with levels of systolic and diastolic blood pressure in type 2 diabetic patients. More attention to the serum uric acid level and treatment of hyperuricemia could halt the progress of diabetic nephropathy.