There is an increasing tendency for traditional medicine in the world. Many people prefer to take herbal products instead of chemical medicines. However, over consumption of herbal medicines has led to many unpredictable side effects.One of these traditional medicines is Citrullus colocynthis, which is used by diabetic patients as an hypoglycemic agent, but it has been reported to cause gastrointestinal disorders after consumption in some patients. Fifty rats were randomly divided into five groups (4 experimental and 1 controls). In the experimental groups a single daily dose of alcoholic extract of Citrullus colocynthis ? (50, 100, 200, 400 g/kg) was administered intraperitonally. Normal saline was administered in control group. After two weeks, the rats were killed and the livers were removed and fixed with formalin (10%). Specimens were then processed and stained with H&E and Reticuline.The results indicated that there is a morphological change in liver cells including karyrrhexis, chromatolysis, and granulation of the cytoplasm. Additionally, collagen and reticular fibers were evident in liver parenchyma in high doses. Citrullus colocynthis can have toxic effects on liver cells which may induce hepatocyte necrosis and liver fibrosis. These effects were dose dependent. Further studies are necessary to clarify the issue.
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机译：在世界范围内，传统医学的趋势正在增加。许多人更喜欢吃草药而不是化学药品。然而，过度食用草药会导致许多无法预料的副作用，其中一种传统药物是Citrullus colocynthis，它被糖尿病患者用作降血糖药，但据报道，某些患者食用后会引起胃肠道疾病。五十只大鼠随机分为五组（4只实验组和1只对照组）。在实验组中，单日剂量的瓜瓜酒精提取物？ （50、100、200、400 g / kg）经腹膜内给药。对照组给予生理盐水。两周后，处死大鼠，取出肝脏并用福尔马林（10％）固定。然后对样品进行处理并用H＆E和网状蛋白染色。结果表明，肝细胞的形态发生了变化，包括咽痛，色谱分离和细胞质颗粒化。另外，高剂量在肝实质中明显存在胶原蛋白和网状纤维。西葫芦可能对肝细胞产生毒性作用，可能诱导肝细胞坏死和肝纤维化。这些作用是剂量依赖性的。有必要进行进一步的研究以澄清该问题。
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