Evaluation of Biochemical Parameters in Controlled and Uncontrolled Type-2 Diabetic Patients of Bangladesh

摘要

Type 2 Diabetes mellitus is one of the most serious public health problems, faced by both developed and developing countries. Patients with type 2 diabetes often show an unusual biochemical profile. Glycosylated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic control. In accordance with its function as an indicator for the mean blood glucose level, HbA1c predicts the risk for the development of diabetic complications in diabetic patients. Therefore the aim of the present study was to investigate the evaluation of biochemical parameters in controlled and uncontrolled type 2 diabetic patients on the basis of glycosylated hemoglobin (HbA1c) level as a control. Venous blood samples collected from 156 subjects (Controlled 45 and Uncontrolled 111) with type 2 diabetes mellitus and serum analyzed for HbA1c, Fasting and after breakfast blood glucose, Total Cholesterol, Triglycerides, HDL, LDL and Electrolytes. All biochemical parameters were measured following standard analytical procedure. The HbA1c and after breakfast glucose level were significantly higher in uncontrolled groups than controlled type 2 diabetic subjects (p0.001 and p0.01respectively). Serum triglyceride level in uncontrolled groups was significantly higher than controlled type 2 diabetic patients (p0.009). Serum Na and Clwas significantly higher (p0.05) in the controlled compared to uncontrolled subjects. Total cholesterol and triglycerides showed significant positive correlation with HbA1c (p0.00 and p0.01 respectively). Cl is negatively correlated with HbA1c and triglyceride (p0.045 and p0.022 respectively). The present study showed thatlipid level is increased and electrolytes level is decreased in uncontrolled type 2 diabetes mellitus and HbA1c may be utilized for early diagnosis of cardiovascular disease and timely intervention with lipid lowering drugs in Type 2 diabetic patients.