Nanotechnology represents one of the most capable technologies of the 21s tcentury. Recently Nanotechnology is emerging in the field of cosmetics and dermal preparations as it offers a revoluti onize treatment of several skin diseases. It is proved effective in attaining Safe and targeted delivery of active medicaments as well cosmetic ingredients. Use of carrier system in nanotechnology has added advantage of improved ski n penetration, depot effect with sustained release drug action. This review article discusses advantages, disadvantages, method of preparation and pharmaceutical applications of various unconventional nanoparticles like Solid Lipid Nanoparticles, Nanostructured Lipid Carrier, and Lipid Drug Carrier and also some novel drug carrier systems like Microsponge Drug Delivery system, Vitamin and Gold loaded Nanofibre facial mask etc. Apart from this it also covers toxicological concern about nanoparticles
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