Synthesis, Characterization, In-vitro Anticancerand Antimicrobial Properties of Some Metal(II)Complexes of 4-[(2,3-dihydro-1H-inden-4-ylimino)methyl] benzene-2,4-diol

摘要

Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) complexes of the Schiff base, 4-[(2,3-dihydro-1H- inden-4-ylimino)methyl]benzene-2,4-diol are synthesized and characterized by microanalysis, conductance, 1HNMR, infrared and electronic spectral measurements. The ligand coordinates through one of the phenolic O and imine N atoms to the metal ions as shown by IR measurements, and electronic measurements are corroborative of a four coordinate, tetrahedral/square-planar geometry for the complexes. The metal complexes are hydrated, forming as [ML2]. aH2O and none is an electrolyte in nitromethane. Cytotoxicity studies reveal that the Pd(II) complex has the best in-vitro anticancer activity against both MCF-7 (human breast adenocarcinoma) and HT-29 (colon carcinoma) cells, with IC50 values of 0.94 μM and 1.67 μM respectively, which exceed the activity of Cis-platin. The antimicrobial study shows that Co(II) and Cu(II) complexes have broad-spectrum antimicrobial activity against Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Samonella typhi with inhibitory zones range of 12-24 mm and 12-20 mm respectively.