EVALUATION OF ANTIMICROBIAL AND TOPICAL ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS AND FORMULATIONS OF CASSIA TORA LEAVES

摘要

Objective: The aim of the present study was to evaluate the antimicrobial and anti-inflammatory activity of Aqueous, alcoholic and hydroalcoholic extracts of Cassia tora linn. leaves and their topical ointment preparations. Methods: Anti inflammatory effect of the leaf extracts and their respective ointment preparations was evaluated topically in rat models using croton-oil-induced inflammation or oedema of the rat ear. Antimicrobial testing of herbal extracts and their formulations was performed for antibacterial and antifungal activities by cup-plate method as per the standard procedure in Indian Pharmacopoeia. Results: Maximum anti-inflammatory activity was seen in Alcoholic and hydroalcoholic extracts and their ointments. The Aqueous extract was found to show maximum antibacterial action against gram Positive bacteria and good antifungal action. However, they show less antibacterial action on gram negative bacteria Conclusion: The results obtained from this study indicate that the tested extracts and their ointments have potential anti-inflammatory activity. The aqueous extract and its ointment was found to possess good antibacterial action against gram positive bacteria and good antifungal activity as well