FORMULATION AND EVALUATION OF MICONAZOLE NITRATE SOAP STRIPS FOR DERMAL INFECTIONS

摘要

In.present.study,.antifungal.paper.soap.strips.of.miconazole.nitrate.were.prepared.&.evaluated.for.dermal.infections.because.the.presence.of.thick.foam.on.the.infected.part.causes.hydration.of.stratum.corneum.for. better.penetration.of.drug..The. formulation.and.evaluation. of.medicated.soap.strips.were.carried.out.in.two.phases..Phase‐I.studies.optimization,.which.was.carried.out.to.study.water.absorption.capacity.using.different.types.of.papers.(Whatman.filter.paper.no..1,.41.and.42,.filter.paper,.bond.paper.and.butter.paper)..by.determining.the.parameters.weight.gain,.size,.shape.and. foam. test.. From. these. parameters. best. soap,. concentration. of.liquid.soap.solution.and.papers.were.selected..Phase‐II.studies. involve.incorporation. of. drug. in. best.soap. solution. and. papers. chosen. from. phase‐I. studies.. The. medicated. soap.strips. were. prepared. by. dipping. the.selected.paper.in.drug.containing.soap.solution..The.prepared.medicated. paper.soap. strips. were.characterized. for.weight. gain,. foam.test,.drug.content.uniformity,.FTIR,.in.vitro.drug.release.studies.using.diffusion.cell.with.hydrated.cellophane.membrane.and.primary.skin.irritation.test...The.microbial. studies. indicate. drug. activity. by. zone. of. inhibition. against. microorganisms. . C.albicans,. S.typhi,. S.aureus,. E.coli,. B.subtilis. and. A.niger.species..The.obtained.results.for.prepared.medicated.soap.strip.of.Miconazole.nitrate.indicate.that.these.strips.are.economic,.convenient,.gives.good.foam.on.application,.uniform.in.drug.content.and.not.showing.any.skin.irritation