Analysis of Miconazole nitrate, econazoEe nitrate, acetic acid chloride with the use of ultraviolet spectrophotometry and chemometrics

摘要

A direct and novel ultraviolet spectrophotometry method for analysis of complex samples was researched and developed with the use of chemometrics, using the Miconazole nitrate, econazole nitrate,acetic acid chloride as example samples. The spectra (range: λ=240~280 nm were processed using Partial least squares (PLS).The ultraviolet spectrophotometry data of the samples were also used to evaluate the samples' quantitative composition.lt was found that the samples were clearly discriminated.A PLS model was developed for simultaneous analysis of the three analytes . The satisfactory prediction results for synthetic samples were obtained by Partial least squares (PLS) as calibration methods (relative prediction error RPET -4.23%).