ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY WATER SOLUBLE DRUG BY SPRAY DRYING USING DIFFERENT GRADE OF CHITOSAN

摘要

Piroxicam.is.a.Non‐steroidal.anti.inflammatory,.analgesic.and.anti‐pyretic.drug.which.is.widely.used.in.Muscle‐skeletal.disorder.like.osteoarthritis..Piroxicam.has.bad.taste,.half.life.of.30.hrs.and.poor.water.solubility..So.the. present.work.was.focused.on. prepare. the.microspheres.to. improve.solubility. and. dissolution. of. piroxicam. using. two. grade.of. chitosan. with. different. drug:.polymer. ratio. by. spray‐drying. technique.. The. effect. of.different. polymers. and. drug–polymer. ratios. on. solubility. and. dissolution. of. microspheres. was. investigated.. The. prepared. microspheres. were.characterized.by.Fourier.transform.infrared.spectroscopy,.Differential. scanning. colorimetric,.XRD.study.and.scanning.electron. microscopy,.Drug.loading.and.drug‐release.properties..Spray.dried.microspheres.of.exhibited.decreased.crystallinity..The.solubility.and.dissolution.of.the.Spray.dried.microspheres.of.both.the.polymers.with.different.ratio.were.improved.compared.with.pure.sample.of.piroxicam..Hence.this.spray.drying.technique.can.be.used.for.formulation.of.tablets.of.piroxicam.by.direct.compression.with.directly.compressible.tablet.excipients