DEVELOPMENT OF COLORIMETRIC METHOD FOR DETERMINATION OF DASATINIB IN BULK AND IN TABLET FORMULATION

摘要

A. simple,. economical,. accurate,. precise. and. reproducible. colorimetric. method. for. the. routine. estimation. of. dasatinib. has. been. develope d.. The.method.is.based.on.the.formation.of.a.blue.colored.complex.by.dasatinib.in.presence.of.folin.ciocalteu.reagent. and.NaOH..The.developed.colored.complex.showed.λmax.at.745.nm..Beer's.law.in.the.concentration.range.of.10.to.80.μg/.ml..Results.of.analysis.were.authenticated.statistically.as.well.as. by. recovery. studies,. which.gave. mean.recovery.between. 99. to. 100%... The. method. was.successful.in. determining. dasatinib. in.physical.mixture.and.in.tablet.formulation,.with.an.average.recovery.of. 99.and.100.%.respectively..The.proposed.method.could.find.application.to.product.development.scientists. in. ongoing. research;. as. well. provide. an. additional. tool. for. routine.analysis. of.dasatinib.in. academia. and. quality.control.