Design and evaluDESIGN AND EVALUATION OFCARBOXYMETHYL TAMARIND KERNEL POLYSACCHARIDE (CMTKP) CONTROLLED RELEAation of Carboxymethyl tamarind kernel polysaccharide (CMTKP) controlled release spheroids/pellets and investigating the influence of compression.

摘要

Objective: The aim of the present work was to design Carboxymethyl tamarind kernel polysaccharide (CMTKP) sustain release spheroids of lornoxicam through extrusion/spheronization technique and to evaluate the effect of compression force on same. Methods: Extrusion/spheronization technique for pellet preparation and tableting for compression of spheroidsinto tablets. Results: The results of micromeritic properties, hausner’s ratio and friability, were within the limit, indicating good flow potential of the prepared spheroids. The drug loaded spheroids were in spherical shape as evidence in SEM photomicrographs. Form the DSC studies it was evident that there was no chemical interaction between the drug used and polymers indicating, that drug was in stable form.The formulation developed using 10% w/w CMTKP, was found to sustain the drug release over a period of 12 h. Conclusion: From the present work, it can be concluded that the prepared matrix spheroid demonstrates the potential use of MCC and CMTKP blend for the development of controlled drug delivery systems for many water insoluble drugs. Keywords: Carboxymethyl tamarind kernel polysaccharide (CMTKP) extrusion-spheronization, roll compacted tablets, Lornoxicam.