INFLUENCE OF FORMULATION FACTORS ON THE SIZE OF NANOSTRUCTURED LIPID CARRIERS AND NANOEMULSIONS PREPARED BY HIGH SHEAR HOMOGENIZATION

摘要

Objective : The main purpose of this work was to elucidate the effect of certain formulation factors on the size of nanostructured lipid carriers (NLCs) and nanoemulsions (NEs) by using high shear homogenization method. Methods : NLCs and NEs were prepared by high shear homogenization method using different liquid lipids types such as (Dermarol DCO? and Dermarol CCT?) at different concentrations. The effect of different concentration ratios of Tween 80 to Span 20 (2.5/1, 5/1, 10/1, 15/1) w/w % and different homogenization speeds (12 000, 18 000 rpm) on the resulted particle size were also studied. Results : The results revealed that the optimum NLCs and NEs resulted when we use Dermarol CCT? with a concentration of 90 % as liquid lipid and decreasing surfactant ratio to (2.5/1) w/w % with increasing the homogenization speed to 18 000 rpm. Conclusion : NLCs and NEs were successfully prepared, and from this study, it can be concluded that NLCs have the optimum particle size than Nanoemulsions.