Alpha 1 -Adrenoceptor Antagonists Improve Memory by Activating N -methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus

摘要

Purpose: Alpha₁ (α₁)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system. Therefore, α₁-adrenoceptor antagonists may enhance brain functions. In the present study, we investigated the effects of tamsulosin, an α₁-adrenoceptor antagonist, on short-term memory, as well as spatial learning and memory, in rats.