CHEMICAL STABILITY STUDIES OF BIOADHESIVE TOPICAL GEL

摘要

The.main.purpose.of.this.work.was.to.study.the.chemical.stability.of.optimized.bioadhesive.topical.gel..For.that.Bioadhesive.topical.gel.formulation.was. optimized. on. the. basis. of. bioadhesive. strength. and. in-vitro. drug. permeation. study. of. prepared. bioadhesive. topical. gel.. To. achieve. the.objectives. of. present. study,. BNTGs. were. prepared. using. natural. bioadhesive. polymer. Aegel. marmelos. (plant. Bale). and. hydroxyethyl. cellulose.(HEC)..Bioadhesive.strength.of.BNTG3.was.found.to.be.1.72±0.023.gm/cm2.. BNTG3.permeates.only.89.00%±0.59%.over. 24.h.. The. shelf. life.of.BNTG3.was.found.to.be.0.439.years.and.0.302.years.at.25±2°C.and.40±2°C,.respectively..Degradation.half‐life.of.BNTG3.was.found.to.be.2.902.years.and.1.996.years.at.25±2°C.and.40±2°C,.respectively..Activation.energy.was.found.to.be.4631.7003.cal/mol..All.the.data.was.found.to.be.extremely.significant. by. studying. one.way.ANOVA.at.p<0.05.level..In.last. it.was.concluded.that,.BNTG3.will.be.more.effective.and.stable.if.it.is. stored. at.or.below.25±2°C..So,.BNTG3.was.successfully.developed.and.standardized.for.improved.topical.therapeutics