A TRANSDERMAL GLUCOSAMINE FORMULATION IMPROVES OSTEOARTHRITIC SYMPTOMS IN AN OPEN CLINICAL SURVEY

摘要

Objective:.To.evaluate.the.efficacy.and.safety.of.a.new.transdermal.formulation.of.glucosamine.in.the.treatment.of.osteoarthritis.(OA)...Method:.Forty.four.(44).patients.with.mild.to.moderate.OA.attending.16.different.outpatient. clinics.in. Singapore.were.recruited.into. the.4‐week.study..Three.criteria.were.used.to.quantify.the.severity. of. disease.activity.evaluated.before.and.after. treatment. with.one.gram. (3. times. daily). of.Urah.transdermal.glucosamine.(UTG).cream.formulation.viz:.Ritchie.articular.index.(RAI),.functional.disability.assessment.[Doctor's.Evaluation.of.Health.status.(DEH)].and.arthritis.self‐efficacy.scale.[Patient's.Assessment.Questionnaire.(PAQ)]...Results:.After.four.weeks,.UTG.treatment.was.observed.to.improved.RAI.pain.score.from.the.baseline.(day.0).in.all.demographic.group.and.further.enhanced.functional.abilities..Overall,.59%.of.the.patients.had .a.good.opinion.rating.for.this.transdermal.formulation.and.showed.beneficial.effects..Efficacy.appeared. to.be.related.to.the. site.of.arthritis.with. 100%.of.patients.having.arthritis.of.the.shoulders. reporting. ben eficial. effects.of.UTG.therapy.as.opposed.to.75%.of.patients.with.ankle,.wrist.and.elbow.OA.and.58%.of.knee.OA.respectively..Additionally,.compliance.to.treatment.was.observed.to.be.over.95%.and.there.were.no.reports.of.adverse.reactions.and.no.skin.irritations.were.observed.at.any.time.point..Conclusion:.Urah.Transdermal.Glucosamine. Cream.significantly. alleviated. pain. in. arthritic.joints. when. applied.over.four.weeks. suggesting.an. improvement.in.the.quality.of.life..This.results.support.further.clinical.trial.into.the.use.of.transdermal.route.of.administration.of.glucosamine