FTIR AND XRD INVESTIGATIONS OF SOME FLUOROQUINOLONES

摘要

The. vibrational. spectroscopy,. such. as. FTIR. has. been. used. to. measure. the. vibrational. modes. of. fluoroquinolones,. provides. inform ation. about.structural. differences. of. its. individual. members.. From. the. interpreted. spectral. data,. Norfloxacin,. Ofloxacin. and. Ciprofloxacin .have.been.distinguished. by. the. presence. of. different. substituents. in. their. parent. nucleus.. X‐ray. powder. diffraction. (XRD). data. of. those. three. pure.fluoroquinolones.have.been.obtained.using. a.powder.diffractometer..The.drugs.were.scanned.from.a.Bragg's. angle.(2θ).of.10.to. 70... The.powder.XRD.patterns.of.all.fluoroquinolones.studied.were.sufficiently.unique.to.make.their.identification.possible..Both.FTIR.and.XRD.studies.provide.the.most. direct. and. definitive. identification. of. fluoroquinolones. and.offer.a.means.for.qualitative.analysis.of.pure.drugs..The.current. preliminary.studies.make.the.basis.for.validation.of.both.FTIR.and.powder.XRD.as.a.good.monitoring.official.method.for.identification.of.fluoroquinolones