ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF CALOTROPIS GIGANTEA SEEDS ON STZ INDUCED DIABETIC RATS

摘要

Objective: The present study was designed to evaluate the anti-diabetic activity of methanolic extract of Calotropis gigantea seeds on streptozotocin induced diabetic rats. Methods: The acute toxicity studies were performed on mice while adopting the OECD-420 Guidelines (fixed dose procedure). The anti-diabetic activity of plant seeds were investigated on the standard 21 days Streptozotocin induced diabetes model. Results: Treatment with methanolic extract of Calotropis gigantea (MECG) seeds at the dose 200 mg/kg and 400 mg/kg body weight, significantly decrease the blood glucose levels from 277.33±5.207 and 294.5±12.26 to 141.5±8.807 and 120.5±9.68 respectively. The activities were also compared with the effects produced by the standard anti-diabetic drug, glimipride 10 mg/kg. Conclusion: The present findings indicate that the seeds of Calotropis gigantea possess potent anti-diabetic effect on streptozotocin diabetic rats