PRELIMINARY STUDIES ON DIURETIC EFFECT OF SPILANTHES ACMELLA LEAVES EXTRACTS IN RATS

摘要

Petroleum.ether,.chloroform.and.alcohol.extracts.of.leaves.of.Spilanthes. acmella..were.evaluated.for.its.diuretic.activity.using.modified.method. of.Rao..The.animals.were.grouped.into.different.groups.of.six.animals.each...All.the.animals.received.priming.dose.of.0.9%.sodium.chloride.solution.(20.ml/kg.body. weight.p.o.)..The. first.group.of.animals,.served. as. control,.received.normal.saline.(20.ml/kg.body.weight. p.o.) ;. the.second. group.received.the.standard.drug.frusemide.(10.mg/kg.body.weight.p.o.).in.0.9%.sodium.chloride.solution.and.The.other.three.groups.received.petroleum.ether,. chloroform,. and. alcohol. extracts. of. Spilanthes. acmella. . leaves. in.a. dose.of. 500.mg/kg. body.weight.suspended. in.0.9%. sodium.chloride.solution.(p.o.)...The.urine.volume.was.recorded.for.all.the.groups.for.5h..and.electrolyte.concentration.(Na+,.K+.and.Cl‐).were.measured..The.extracts.showed.increase.in.total.urine.volume.and.electrolytes.excretion. (sodium. Na+,. potassium.K+.and.chloride.Cl‐)..So,.Out.of.the.different.extracts,.the.alcohol. extract.(500.mg/kg).significantly.and.markedly.increased.the.urine.output.(p.<.0.01)..The.pattern.of.diuresis.induced.by.the.alcohol. extract. was. almost. similar. to. that. produced. by. the. frusemide.. These. findings. suggest. the. possible. traditional. use. of. this. plant. in.hypertension.as.diuretics.are.used.in.the.management.of.hypertension