HYPOLIPIDEMIC, HYPOGLYCEMIC AND ANTIOXIDANT POTENTIAL OF SARACA ASOCA ETHANOLIC LEAVESEXTRACT IN STREPTOZOTOCIN INDUCED- EXPERIMENTAL DIABETES

摘要

Objective: To investigate the hypolipidemic, hypoglycemic and antioxidant potential of Saraca asoca ethanolic leaves extract in streptozotocin induced- experimental diabetes. Method: Experimental hyperglycemia was produced in rats by single dose of Streptozotocin (55 mg/kg). Assessment of blood glucose, TBARS and GSH was used as marker of hyperglycemia and oxidative stress respectively. Serum lipid profile (total cholesterol, HDL and triglyceride) were used as markers of dyslipidaemia. Result: Treatment with Saraca asoca ethanolic extract normalizes the altered lipid profile and reduced the elevated glucose level in dose dependent manner. Further it attenuates the diabetes-induced renal oxidative stress. Conclusion: Concurrent administrations of Saraca asoca ethanolic extract reducing the lipid alteration, decreasing the renal oxidative stress and certainly provide hypolipidemic, hypoglycemic and antioxidant effect