FORMULATION DEVELOPMENT AND EVALUATION OF DELAYED RELEASE DOXYCYCLINE TABLETS

摘要

The. main. purpose. of. this. work. is. to. develop. small. intestine. targeting. tablets. of. doxycycline. hydrochloride. by. wet.granulation. method. and. enteric. coating. of. tablets. (conventional. standard. coating. technique).This. drug. is. universal.antibiotic. and. can. be. targeted. to. the. specific. site. of. absorption. by. enteric. coating. using. pH. dependant. polymers..Polymers. like. Eudragit. and. HPMC. Phthalate. are. selected. where. dissolution.is.above.pH.6.and.pH.6.4.respectively..Preformulation.studies.like. angle. of.repose,.bulk. density,. tapped. density,.porosity,. Carr's. index,.Hausner's. ratio. were.performed..Six.batches.(F1.to.F6).were.formulated.and.evaluated. for. hardness,. friability,. weight. variation,. drug.content,. disintegration. and.in‐vitro.dissolution.. Among. the.six.batches,.batch.F4.was.showing.94%.drug.release.and