DESIGN AND IN VITRO EVALUATION OF MUCOADHESIVE BUCCAL FILMS CONTAINING FAMOTIDINE

摘要

The.buccal.region.offers.an.attractive.route.of.administration.for.systemic.drug.delivery..A.buccal.patch.for.systemic.administration.of.famotidine.in.the.oral. cavity. has.been.developed. using.hydroxypropylmethylcellulose,.sodium.carboxymethylcellulose. (SCMC).and.polyvinyl. alcohol. by. solvent.casting.method.. The.physicochemical. interactions. between.and. polymers. were. investigated.by. Fourier. transform. infrared. (FTIR).Spectroscopy..According.to.FTIR.the.drug.did.not.show.any.evidence.of.an.interaction.with.the.polymers.used.and.was.present.in.an.unchanged.state..The.patches.were.evaluated.for. their. physical.characteristics. like. weight. variation,.thickness,.drug. content.uniformity,. surface. pH,. folding. endurance,. tensile.strength,. mucoadhesion.strength,.In. vitro.release. studies.were. conducted. for.famotidine.patches.in.phosphate.buffer. (pH,.6.6). solution.. Patches.exhibited.drug.release.in.the.range.of.72.58.to.91.91%.in.20.min